慢性剥離性歯肉炎について : 螢光抗体法による検索

概要

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Chronic desquamative gingivitis is a common clinical manifestation of a number of diseases. This study was performed to determine the immunological status of this disease. Observations on 4 patients with desquamative lesions in the mouth, not on the skin and eyes, were as follows: 1. IgG and IgA serum levels were normal, while IgM and IgE serum levels were lower than normal. The 50% hemolysis level (CH_<50>) was normal in three of the cases; the second case had an elevated level. 2. The direct immunofluorescent method revealed diffuse IgG deposition in connective tissue without epithelium; IgA, IgM and IgE were not found. C1q and C3 were not found in the tissue samples. 3. The indirect immunofluorescent method revealed the following: (1) Case 1: IgM, C1q and C3 appeared as nuclear ataining in epithelium. Deposits of C1q localized in nucleus of the basal layer of epithelium. (2) Case 2: In the first collected serum, deposits of IgM were only found as a reticulate pattern in the basal layer of epithelium. In the serum collected 4 months later, however, both IgG and IgM showed positive reticulate patterns in the basal layer. Other globulins and complements were negative. (3) Case 3: Deposits were not found. 4. There was no relationsip of immunoglobulins and complements between serum and biopsies. 5. There was nothing in common with specific positive patterns in the experimented cases.
特定非営利活動法人日本歯周病学会の論文
1981-09-28