Hypergravity Effect on TRAP and Cathepsin K mRNA Expression in Cultured Osteoclasts

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概要

• 論文の詳細を見る

• Microgravity in space has been reported to enhance bone resorption in vitro and in vivo, however, the gravity effect on bone remodeling is not well understood. In particular, there are only a few reports about gravity effect on osteoclasts. In the present study, we examined the hypergravity effect on mRNA expressions of osteoclast marker enzymes such as TRAP (tartrate-resistant acid phosphatase) and cathepsin K. Osteoclasts were exposed to 30 x g for 2hr or 18hr. Results suggested that hypergravity enhanced the mRNA expression of both enzymes with different manner; the expression of the TRAP showed a slight increase, that of the cathepsin K showed a non-monotonous time course with maximum hypergravity effect for short time (2hr) incubation.

• 日本再生歯科医学会の論文
• 2004-12-30

著者

• Uemura Toshimasa

  Aist(national Institute Of Advanced Industrial Science And Technology)

• Nemoto Atsuko

  Adrc(age Dimension Research Center)

関連論文

• Hypergravity Effect on TRAP and Cathepsin K mRNA Expression in Cultured Osteoclasts

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