Antinociceptive and Anti-inflammatory Properties of Corchorus capsularis Leaves Chloroform Extract in Experimental Animal Models

概要

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The antinociceptive and anti-inflammatory properties of Corchorus capsularis leaves chloroform extract were investigated in experimental animal models. The antinociceptive activity was measured using the writhing, hot plate and formalin tests, while the anti-inflammatory activity was measured using the carrageenan-induced paw edema test. The extract, obtained after 72h soaking of the air-dried leaves in chloroform followed by in vacua evaporation to dryness, was weighed and prepared by serial dilution in DMSO in the doses of 20, 100 and 200mg/kg. The extract was administered (s.c.) 30 min prior to subjection to the respective assays. The extract was found to exhibit significant (p<0.05) antinociceptive and anti-inflammatory activities. As a conclusion, the present study confirmed the traditional claims of using C. capsularis to treat various ailments related to inflammation and pain.
公益社団法人日本薬学会の論文
2007-02-01