Effects of Highly or Relatively Selective 5-HT_<1A> Receptor Agonists on Lordosis in Female Rats(Endocrinology)
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the role of serotonin (5-HT) receptor 1A or 7 in regulating lordosis behavior in female rats, ovariectomized rats were treated with 3 kinds of receptor agonists and lordosis behavior was observed. The injected agents were the selective 5-HT_<1A> receptor agonist, buspirone (BUS), the highly selective 5-HT_<1A> receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin ((±)8-OH-DPAT), and the 5-HT_<1A> and 5-HT_7 receptor agonist, (R)-8-hydroxy-2-(di-n-propylamino) tetralin ((+)8-OH-DPAT). A behavioral test was performed after ovariectomy and subcutaneous implantation of a silicon tube containing estradiol. Female rats in which the lordosis quotient (LQ) was over 70 were intraperitoneally injected with several doses of these agents. As a result, in the BUS group, the dose of 3mg/kg bw, but not 1mg/kg was effective for suppressing lordosis. On the other hand, an inhibitory effect was observed from 0.25mg/kg and 0.5mg/kg in the (+)8-OH-DPAT and (±)8-OH-DPAT groups, respectively. In the time-course experiment, in all drug-treated groups, LQ decreased to lower than 20 after 15min and low LQ continued for 1 hr at least. Measurement of locomotor activity using an infrared sensor system showed no relation between the decrease in lordosis by these agents and spontaneous locomotion. These results indicate that 5-HT__<1A> is strongly involved in the lordosis-inhibiting circuit of the serotonin neurons.
- 社団法人日本動物学会の論文
- 2003-09-25
著者
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Yamanouchi Korehito
Laboratory Of Neuroendocrinology Department Of Human Behavior And Environment Sciences Faculty Of Hu
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Yamanouchi Korehito
Neuroendocrinology Department Of Human Behavior And Environment Sciences Faculty Of Human Sciences W
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KISHITAKE Miki
Laboratory of Neuroendocrinology, Department of Human Behavior and Environment Sciences, Faculty of
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Kishitake Miki
Laboratory Of Neuroendocrinology Department Of Human Behavior And Environment Sciences Faculty Of Hu
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Kishitake Miki
Laboratory Of Neuroendocrinology Department Of Human Behavior And Environment Sciences School Of Hum
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Yamanouchi K
Neuroendocrinology Department Of Human Behavior And Environment Sciences Faculty Of Human Sciences W
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Yamanouchi Korehito
Laboratory Of Neuroendocrinology Department Of Basic Human Sciences School Of Human Sciences Waseda
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