ロジウム触媒を用いる有機フッ素化合物の新反応の開発

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概要

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• Novel fluoroalkylated products where a CF_2COOEt group was introduced at the α-position of α,β-unsaturated ketones or the Reformatsky-type products have been obtained selectively by the reaction of BrCF_2COOEt and α,β-unsaturated ketones with Et_2Zn in the presence of RhCl(PPh_3)_3 depending on the solvents. Furthermore, the novel α-fluoroalkylated products could synthesize by using various halofluoroalkyl compounds (R_f-X) instead of BrCF_2COOEt. On the other hand, this Reformatsky-type reaction by imines gave difluoro-β-lactams or 3-amino-2,2-difluorocalboxylic esters without or with MgSO_4・7H_2O, selectively.

• 2006-08-01

著者

• 佐藤 和之

  摂南大学薬学部

関連論文

• ロジウム触媒を用いる有機フッ素化合物の新反応の開発
• 好気的条件下での新規な銅触媒C-P結合形成反応

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