Dose Dependent Elevation of Plasma Tocotrienol Levels and Its Effect on Arterial Compliance, Plasma Total Antioxidant Status, and Lipid Profile in Healthy Humans Supplemented with Tocotrienol Rich Vitamin E

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概要

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• Tocotrienols are a class of vitamin E reported to be potent antioxidants, besides having the ability to inhibit the HMG-CoA reductase enzyme. This study assessed the effects of 3 doses of tocotrienol-rich vitamin E (TRE) on plasma tocotrienol isomer concentration, arterial compliance, plasma total antioxidant status (TAS), aortic systolic blood pressure (ASBP), serum total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) in healthy males. Methodology: This randomised, blinded end-point, placebo-controlled clinical trial with a parallel design involved 36 healthy male subjects who took either an oral placebo or TRE at doses of 80, 160 or 320mg daily for 2 mo. Baseline and end-of-treatment measurements of vitamin E concentration, arterial compliance [assessed by aortic femoral pulse wave velocity (PWV) and augmentation index (AI)], ASBP, plasma TAS, serum TC and LDL-C were taken. Results: Baseline tocotrienol isomer concentrations were low and not detectable in some subjects. Upon supplementation, all TRE-treated groups showed significant difference from placebo for their change in α, γ and δ tocotrienol concentrations from baseline to end of treatment. There was a linear dose and blood level relationship for all the isomers. There was no significant difference between groups for their change in PWV, AI, plasma TAS, ASBP, TC or LDL-C from baseline to end of treatment. Groups 160mg (p=0.024) and 320mg (p=0.049) showed significant reductions in their ASBP. Group 320mg showed a significant 9.2% improvement in TAS. Conclusion: TRE at doses up to 320mg daily were well tolerated. Treatment significantly increased α, δ, and γ tocotrienol concentrations but did not significantly affect arterial compliance, plasma TAS, serum TC or LDL-C levels in normal subjects.

• 日本ビタミン学会の論文

著者

• Rahman Abdul

  Cyberjaya University College Of Medical Sciences

• RASOOL Aida

  School of Medical Sciences, Universiti Sains Malaysia

• YUEN Kah

  School of Pharmaceutical Sciences, Universiti Sains Malaysia

• YUSOFF Khalid

  Universiti Teknologi MARA

• WONG Abdul

  School of Medical Sciences, Universiti Sains Malaysia

• Wong Abdul

  School Of Medical Sciences Universiti Sains Malaysia

• Yuen Kah

  School Of Pharmaceutical Sciences Universiti Sains Malaysia

• Rasool Aida

  School Of Medical Sciences Universiti Sains Malaysia

関連論文

• Dose Dependent Elevation of Plasma Tocotrienol Levels and Its Effect on Arterial Compliance, Plasma Total Antioxidant Status, and Lipid Profile in Healthy Humans Supplemented with Tocotrienol Rich Vitamin E
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