N-Terminal ProBNP Levels Can Predict Cardiac Failure After Cardiac Surgery

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Background The aim of this study was to evaluate the relationship between the preoperative N-terminal proB-type natriuretic peptide (NT-proBNP) level and the need for the inotropic support in the early postoperative period of patients undergoing coronary artery bypass graft surgery. Methods and Results The patients were divided into 2 groups: NT-proBNP level <220pg/ml (group A, n=26) or >220pg/ml (group B, n=26). The normal value for NT-proBNP level was accepted as <220pg/ml. The cardiac output was measured on arrival in intensive care and at the 16^<th> hour. The groups were compared with respect to early postoperative hemodynamic measurements, urinary output, use of inotropic agents and requirement for additional cardiac-assist devices. Left ventricular ejection fraction, cardiac output and cardiac index were lower in group B and inotropic agents were used for a longer period of time and at higher doses in this group (p<0.05). Conclusion Measurement of the NT-proBNP level in the period before cardiac surgery can indicate the postoperative prognosis of the patient and may be a predictor of the need for postoperative inotropic treatment.
2006-12-20