Ledgerline, a Novel Xenopus laevis Gene, Regulates Differentiation of Presomitic Mesoderm During Somitogenesis(Developmental Biology)
スポンサーリンク
概要
- 論文の詳細を見る
Segmentation of the vertebrate body via the sequential formation of somites is an important process in embryogenesis. This sequential process is governed by the activation and regulation of Notch-related molecular oscillators by fibroblast growth factor and retinoic acid (RA) signaling. In this study, we identified ledgerline, a novel gene of Xenopus laevis expressed specifically in the presomitic mesoderm. Knockdown of ledgerline using antisense morpholino oligonucleotides shifted the developing somite front and altered the expression of genes that regulate molecular oscillation, including Delta2, ESR5, Hairy2a, and Thylacinel. Knockdown of ledgerline also down-regulated RALDH-2 expression. Injection of RARα-CA, a constitutively active mutant of the RA receptor RARα, subsequently reduced the altered Thylacinel expression. These results strongly suggest that ledgerline is essential for mesodermal RA activity and differentiation of the presomitic mesoderm during Xenopus somitogenesis.
- 社団法人日本動物学会の論文
- 2006-08-25
著者
-
Satow Reiko
Department Of Biological Sciences Graduate School Of Science The University Of Tokyo
-
Kato Shigeaki
The Institute Of Molecular And Cellular Biosciences University Of Tokyo
-
ASASHIMA Makoto
International Cooperative Research Project (ICORP), Japan Science and Technology Corporation (JST)
-
Chan Techuan
International Cooperative Research Project (ICORP) by JST (Japan Science and Technology Agency), Gra
-
Kitagawa Hirochika
The Institute of Molecular and Cellular Biosciences, University of Tokyo
-
Chan Techuan
International Cooperative Research Project (icorp) By Jst (japan Science And Technology Agency) Grad
-
Kitagawa Hirochika
The Institute Of Molecular And Cellular Biosciences University Of Tokyo
-
Kato Shigeaki
The Institute Of Molecular And Cellular Bioscences The University Of Tokyo
-
Asashima Makoto
International Cooperative Research Project (icorp) By Jst (japan Science And Technology Agency) Grad
関連論文
- Abstracts from the 43rd Kansai Calcium Conference October 16, 1999 Osaka Ohbayashi Bldg., Osaka, Japan
- Role of TSC-22 during early embryogenesis in Xenopus laevis
- Ledgerline, a Novel Xenopus laevis Gene, Regulates Differentiation of Presomitic Mesoderm During Somitogenesis(Developmental Biology)
- MOLECULAR MECHANISM OF TRANSCRIPTIONAL CONTROL BY NUCLEAR STEROID HORMONE RECEPTORS
- Estrogen Receptor-Mediated Cross-Talk with Growth Factor Signaling Pathways
- 21S1A-09-3 Molecular Mechanism of Transcriptional Control by Nuclear Steroid Hormone Rceptors.