Novel Microbial Transformations of Sclareolide

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概要

• 論文の詳細を見る

• Fungal catalysis of sclareolide (1) using Mucor plumbeus (ATCC 4740), Cunninghamella blakesleeana (ATCC 9245), Cunninghamella echinulata (ATCC 9244), Curvularia lunata (ATCC 12017) and Aspergillus niger (ATCC 1004), was performed. Cunninghamella blakesleeana (ATCC 9245) metabolized compound 1 to afford O^6-sclareolide (2), 3β,6α-dihydroxysclareolide (3), 9-hydroxysclareolide (4), along with three known metabolites, 1β,3β-dihydroxysclareolide (5), 3-oxosclareolide (6) and 3β-hydroxysclareolide (7). Biotransformation experiments of compound 1 with Cunninghamella echinulata (ATCC 9244) also yielded two new compounds, 5-hydroxysclareolide (8), and 7β-hydroxysclareolide (9) along with two known compounds 5 and 7. Spectroscopic methods were used to establish the structures of compounds 2-9. Compounds 2-9 exhibited modest acetylcholinesterase inhibitory activity.

• 公益社団法人日本薬学会の論文
• 2007-01-01

著者

• SENER Bilge

  Department of Pharmacognosy, Faculty of Pharmacy, Gazi University

• Orhan Ilkay

  Department Of Chemistry The University Of Winnipeg:department Of Pharmacognosy Faculty Of Pharmacy G

• Sener Bilge

  Department Of Pharmacognosy Faculty Of Pharmacy Gazi University

• Ata Athar

  Department Of Chemistry The University Of Winnipeg

• CONCI Leigha

  Department of Chemistry, The University of Winnipeg

• BETTERIDGE Jordan

  Department of Chemistry, The University of Winnipeg

• Betteridge Jordan

  Department Of Chemistry The University Of Winnipeg

• Conci Leigha

  Department Of Chemistry The University Of Winnipeg

関連論文

• Isoflavonoid Glycosides from the Rhizomes of Iris germanica
• New Steroidal Alkaloids from Fritillaria imperialis and Their Cholinesterase Inhibiting Activities
• Glutathione S-Transferase Inhibiting Chemical Constituents of Caesalpinia bonduc
• Novel Microbial Transformations of Sclareolide
• Mucoralactone A: An Unusual Steroid from the Liquid Culture of Mucor plumbeus

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