Effects of Plant Lactones on the Production of Biofilm of Pseudomonas aeruginosa

概要

論文の詳細を見る
Sixteen plant sesquiterpene lactones, thirteen from four species of the Family Asteraceae, and three from a species of Hepaticae, as well as seven annonaceous acetogenins isolated from the seeds of the tropical tree Annona cherimolia (Family Annonaceae), were evaluated for their ability to inhibit or stimulate the production of biofllm by a strain of Pseudomonas aeruginosa. The tested compounds carry a γ-lactone moiety in their structures. This structural feature is similar to the lactone moiety present in N-acyl homoserine lactones, compounds that play the important role of "quorum sensors" in the mechanisms of biofilm formation observed in many gram-negative bacteria. A special assay was employed to evaluate the influence of the tested plant compounds to inhibit or stimulate the production of biofilm in a P. aeruginosa wild strain. Most of the tested compounds affected the biofilm formation mechanism. Six sesquiterpene lactones isolated from Acanthospermum hispidum and one from Enydra anagallis as well as an acetogenin from Annona cherimolia strongly inhibited (69-77%) the biofilm formation when incorporated to a bacterial culture at a concentration of 2.5μg/ml. However, one of the acetogenins, squamocin, stimulated the biofilm formation even at a concentration of 0.25μg/ml. The study of substances affecting the biofilm formation can lead to the design of new strategies to control P. aeruginosa infections.
公益社団法人日本薬学会の論文
2007-01-01

Effects of Plant Lactones on the Production of Biofilm of Pseudomonas aeruginosa

スポンサーリンク

概要

著者

関連論文

スポンサーリンク