Protective Effect of Ginsenoside-Re against Cerebral Ischemia/Reperfusion Damage in Rats(Pharmacology)

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概要

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• To investigate the protective effect of ginsenoside Re (Re) against cerebral ischemia-reperfusion injury, adult male Wistar rats weighing 250-300g were subjected to either sham surgery or middle cerebral artery occlusion (MCAO) for 2 h of brain ischemia and 2 h reperfusion. A fluorescence polarization assay was carried out for membrane fluidity of brain mitochondria. Lipid peroxidation [malondiadehyde (MDA) formation], superoxide dismutase (SOD) and glutathion peroxidase (GSH-Px) of rat brain were estimated by fluorometric methods. It was observed that Re (5, 10, 20mg kg^<-1> p.o. pretreatment for 7 d, once a day) significantly improved the fluidity of mitochondrial membranes as demonstrated by a reduction of average microviscosity, ameliorated lipid peroxidation by raising the activities of SOD and GSH-Px, and reduced the content of MDA in rat brain. This study demonstrated a direct protective effect of Re against cerebral ischemia-reperfusion injury.

• 公益社団法人日本薬学会の論文
• 2006-12-01

著者

• Zhou Xiao-mian

  Department Of Pharmacology Shenyang Pharmaceutical University

• CAO Ying-Lin

  Department of Pharmacology, Shenyang Pharmaceutical University

• DOU De-Qiang

  Department of Pharmacology, Shenyang Pharmaceutical University

• Dou De-qiang

  Department Of Pharmacology Shenyang Pharmaceutical University

• Cao Ying-lin

  Department Of Pharmacology Shenyang Pharmaceutical University

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• Protective Effect of Ginsenoside-Re against Cerebral Ischemia/Reperfusion Damage in Rats(Pharmacology)

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