Insect cytokine growth-blocking peptide (GBP) regulates insect development
スポンサーリンク
概要
- 論文の詳細を見る
Growth-blocking peptide (GBP) was first identified in the hemolymph of the host armyworm, Pseudaletia separata, whose growth is halted in the last instar larval stage by parasitization with the parasitoid wasp, Cotesia kariyai. Studies on the mechanism of growth retardation by GBP revealed that GBP titers in hemolymph fluctuate synchronously with dopamine levels: GBP and dopamine peaks coincide with each larval molt period, during which larvae temporarily cease moving and feeding. The fact that GBP induced the elevation of dopamine concentration in the hemolymph was demonstrated in armyworm larvae by GBP injection. Dopamine elevation was also observed in insects exposed to various stress conditions such as parasitization and chilling. These results, together with the fact that dopamine itself inhibits larval growth, indicate that GBP induces growth retardation via the elevation of dopamine levels. Further, we demonstrated that the diapause-inducing influence of short day length also elevates dopamine concentrations in hemolymphs and the brain-central nervous system (Br-CNS) of the cabbage armyworm, Mamestra brassicae. The elevation of dopamine levels contributes to the onset of pupal diapause. We therefore proposed that a GBP-dopamine system contributes to the control of growth rates in insects. Recent studies by ourselves and other laboratories have found more than 10 homologous peptides in various insect species. These peptides have diverse functions: larval growth retardation, paralysis induction, cell proliferation, immune cell stimulation and cardioacceleration. As demonstrated, GBP itself exerts most of these functions, so it is reasonable to conclude that GBP and GBP-like peptides widely present in insects should be regarded as insect cytokines with a variety of functions.
- 2006-11-25
著者
-
HAYAKAWA Yoichi
Department of Applied Biological Sciences, Faculty of Agriculture, Saga University
-
Hayakawa Yoichi
Faculty Of Agriculture Saga University
-
Hayakawa Yoichi
Departmen Of Applied Biology Saga University
-
Hayakawa Yoichi
Department Of Applied Biological Science Saga University
関連論文
- Burkholone, A New Cytotoxic Antibiotic against IGF-I Dependent Cells from Burkholderia sp.
- Effect of C-terminal Elongation on the Structure and Larval Growth Inhibitory Activity of Growth Blocking Peptide (GBP)
- A Novel Cytokine from the Larval Integument of the Armyworm, Pseudaletia separata : Isolation, Activities, and NMR Solution Structure
- Structure of Thioviridamide, a Novel Apoptosis Inducer from Streptomyces olivoviridis
- Thioviridamide, a Novel Apoptosis Inducer in Transformed Cells from Streptomyces olivoviridis
- Structure of Tyroscherin, an Antitumor Antibiotic against IGF-1-dependent Cells from Pseudallescheria sp
- Contribution of N-terminal and Loop Regions of GBP to the Interaction with Epidermal Growth Factor Receptor
- CHARACTERIZATION OF SMALL COGNATE CYTOKINES BROADLY OCCURRING IN INSECTS(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- 3P-064 昆虫由来新規ケモカインHCPの解析(蛋白質-機能(反応機構,生物活性など),第47回日本生物物理学会年会)
- Solution Structure of an Insect Growth Factor Peptide GBP and its EGF Activity
- Efrapeptin J, a New Down-regulator of the Molecular Chaperone GRP78 from a Marine Tolypocladium sp.
- Insect cytokine growth-blocking peptide (GBP) regulates insect development
- PURIFICATION AND CHARACTERIZATION OF SILKWORM PARALYTIC PEPTIDE PROCESSING ENZYME FROM HEMOLYMPH(Biochemistry,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- 1P003 NMR solution structure of a novel cytokine from the larval integument of the armyworm, Pseudaletia separata(1. Protein structure and dynamics (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- 1P001 Structure-activity relationships and C-terminal elongation effects of growth-blocking peptide(1. Protein structure and dynamics (I),Poster Session,Abstract,Meeting Program of EABS & BSJ 2006)
- Mutational Analysis of the Small Cytokine : Growth-Blocking Peptide (GBP) to Investigate the Interaction with Its Receptor in Insect Immune Cells
- DISTRIBUTION OF NEURONS IMMUNOREACTIVE TO DOPAMINE AND DOPA DECARBOXYLASE IN THE CENTRAL NERVOUS SYSTEM OF MAMESTRA BRASSICAE(Endocrinology,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- EFFECT OF DEXAMETHASONE ON THE CHANGE OF LYSOSOMAL ENZYME ACTIVITY IN VARIOUS ORGANS OF PREGNANT OR FETAL RATS TREATED WITH METHYLAZOXY-METHANOL
- Structures of New Cytotoxic Antibiotics, Piericidins C_7 and C_8
- Piericidins C_7 and C_8, New Cytotoxic Antibiotics Produced by a Marine Streptomyces sp.
- CLONING OF GROWTH-BLOCKING PEPTIDE (GBP)-INDUCIBLE PHOSPHORYLATED PROTEIN THAT IS INVOLVED IN HEMOCYTE ACTIVATION(Biochemistry,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- IDENTIFICATION OF GBP-INDUCIBLE PHOSPHORYLATED PROTEIN THAT IS INVOLVED IN HEMOCYTE ACTIVATION(Biochemistry,Abstracts of papers presented at the 75^ Annual Meeting of the Zoological Society of Japan)
- PRIMARY CAUSE OF COLOR PATTERN FORMATION IN THE INSECT LARVAE(Biochemistry,Abstracts of papers presented at the 76^ Annual Meeting of the Zoological Society of Japan)
- Ammocidins B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp. AJ9571
- Flaviogeranin, a new neuroprotective compound from Streptomyces sp.
- Hatomarubigin E, a biosynthetic intermediate of hatomarubigins C and a substrate of HrbU O-methyltransferase
- Dechlororoseophilin : a new cytotoxic metabolite from Streptomyces griseoviridis
- Prodigiosin biosynthesis gene cluster in the roseophilin producer Streptomyces griseoviridis