Reconstruction of Rabbit Experimental Mandibular Defect with rhBMP-2 and Atelocollagen Gel : μCT Observation in Vivo and Histological Examination(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)
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概要
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A rabbit experimental mandibular defect was reconstructed with rhBMP-2 and atelocollagen gel, and examined using μCT (R_mCT, Rigaku Mechatronics, Tokyo) in vivo and histological techniques. Using eight rabbits, we made an experimental mandibular defect and filled it with 1% atelocollagen gel including rhBMP-2 10ig (Astellas Pharma Inc.). In μCT observation, the density was slightly elevated at the bone marrow side at one week, and the phenomenon gradually expanded during the course of this experiment. Histologically, mesenchymal cell proliferation and immature bone formation occurred at one week, and mature bone gradually increased and filled in at four weeks.
- 硬組織再生生物学会の論文
著者
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Okafuji Norimasa
Department of Hard Tissue Research, Matsumoto Dental University Graduate School of Oral Medicine
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Okafuji Norimasa
Department Of Orthodontics Matsumoto Dental University School Of Dentistry
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Okafuji Norimasa
Department Of Hard Tissue Research Matsumoto Dental University Graduate School Of Oral Medicine
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