The Effects of Endogenous BMP During The Process of BMP-Induced Bone Formation and A Possibility of Clinical Application(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)

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概要

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• The participation of endogenous BMP-2 in the process of ectopic osteoinduction by rhBMP-2 implanted into rat muscles was investigated using immunohistochemistry, immunoelectron microscopy, in situ hybridization and real-time RT-PCR. Our results suggested that not only implanted exogenous rhBMP-2 but also endogenous BMP-2 produced by osteogenic and/or chondrogenic cells participates in the rapid progression of ectopic bone formation cascade. Since the statins promote the expression of endogenous BMP-2 and enhance the bone formation, we next examined the stimulative effect of statins on the rhBMP-2-induced osteogenesis, by radiological and biochemical analysis, and histology. These results indicated that subcutaneously inj ected simvastatin promotes rhBMP-2-induced ectopic bone formation by reducing bone turnover. Simvastatin may become a useful adjuvant therapy for enhancing BMP-2 induced bone formation.

• 硬組織再生生物学会の論文

著者

• Sugiyama Takeo

  Division Of Oral And Maxillofacial Surgery Mie University Graduate School Of Medicine

• Tagawa Toshiro

  Division Of Oral And Maxillofacial Surgery Mie University Graduate School Of Medicine

• Nakagawa Toshiyuki

  Division of Oral and Maxillofacial Surgery, Mie University Graduate School of Medicine

• Murata Taku

  Division of Oral and Maxillofacial Surgery, Mie University Graduate School of Medicine

• Nakagawa Toshiyuki

  Division Of Oral And Maxillofacial Surgery Mie University Graduate School Of Medicine

• Murata Taku

  Division Of Oral And Maxillofacial Surgery Mie University Graduate School Of Medicine

関連論文

• The Effects of Endogenous BMP During The Process of BMP-Induced Bone Formation and A Possibility of Clinical Application(International Symposium of Maxillofacial and Oral Regenerative Biology in Okayama 2005)

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