Antileishmanial Activity of Natural Diterpenes from Cistus sp. and Semisynthetic Derivatives Thereof(Pharmacognosy)
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概要
- 論文の詳細を見る
Eleven cis-clerodane diterpenes, seven labdane type diterpenes and one triterpene isolated from Cistus monspeliensis and the resin "Ladano" of Cistus creticus subsp. creticus were evaluated against Leishmania donovani promastigotes, the causative agent for visceral leishmaniasis. In addition, eleven semisynthetic manoyl oxide, seventeen labdane type derivatives and a triterpene were also evaluated for their antileishmanial activity. 18-Ace-toxy-ds-clerod-3-en-15-ol, 15,18-diacetoxy-cis-clerod-3-ene and 13-(E)-8α-hydroxylabd-13-en-15-ol 2-chloroethylcarbamate exhibited the most potent and selective leishmanicidal activity with IC_<50> values of 3.3μg/ml, 3.4μg/ml and 3.5μg/ml, respectively.
- 公益社団法人日本薬学会の論文
- 2006-08-01
著者
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Kalpoutzakis Eleftherios
Division Of Pharmacognosy And Natural Products Chemistry Faculty Of Pharmacy University Of Athens
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Duke Stephen
Natural Products Utilization Research Unit Usda Ars P.o. Box 8048 University Of Mississippi
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Duke Stephen
Natural Products Utilization Research Unit Agricultural Research Service United States Department Of
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TEKWANI Babu
National Center for Natural Products Research, School of Pharmacy, University of Mississippi
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Fokialakis Nikolas
Natural Products Utilization Research Unit Usda Ars P.o. Box 8048 University Of Mississippi
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Skaltsounis Alexios
Division Of Pharmacognosy And Natural Products Chemistry Faculty Of Pharmacy University Of Athens
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Tekwani Babu
National Center For Natural Products Research School Of Pharmacy University Of Mississippi
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- Antileishmanial Activity of Natural Diterpenes from Cistus sp. and Semisynthetic Derivatives Thereof(Pharmacognosy)
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