Andrographolide Inhibits the Production of TNF-α and Interleukin-12 in Lipopolysaccharide-Stimulated Macrophages : Role of Mitogen-Activated Protein Kinases(Molecular and Cell Biology)

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Andrographolide has been reported to possess a variety of pharmacological activities. In this study, we have investigated the effect of andrographolide on the production of TNF-α and IL-12 (Interleukin-12) in murine peritoneal macrophages. Andrographolide decreased TNF-α, IL-12a and IL-12b at mRNA level, and reduced the production of TNF-α and IL-12p70 proteins in a concentration-dependent manner. Furthermore, we have found that addition of andrographolide inhibited the activation of ERK1/2 MAP kinase, but not that of JNK, p38 or NF-κB. These results suggested that andrographolide inhibit LPS-induced production of TNF-α via suppression of the ERK1/2 signaling pathway.
公益社団法人日本薬学会の論文
2006-02-01