Reproductive Effects of Ethnomedicinal Formulation of Tape-Vine Leaves in Female Rats(Pharmacognosy)

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概要

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• Documented ethno-contraceptive use of Tape-vine or Stephania japonica (THUNB.) MIERS., Syn. Stephania hernandifolia (WILLD.) WALP. leaves is evaluated with regards to post-coital pregnancy interceptive activity of its aqueous extract (AE) and an ethnomedicinal formulation (EF) in Wistar rats. EF at 500 and 250mg/kg doses induced 66.7% and 33.3% post-coital pregnancy interception respectively and the higher dose exhibited significant reduction in number of litters born and also anti-implantation property. In contrast, none of the dose levels of AE interfered in pregnancy but significant anti-implantation property was observed at doses of 2 and 1g/kg, even as the higher dose produced significant reduction in number of litters born as well. EF at 500mg/kg also exhibited significant uterotrophic activity and histological changes in uterus. Pair-wise comparison of sex hormone-levels exhibited significant increment in serum estradiol, LH and FSH but decrease in progesterone levels. Assessed blood lipid-carbohydrate profile exhibited substantial decrease in glucose, cholesterol, VLDL and triglyceride contents and significant increase in HDL. It is concluded that EF probably acts as better post-coital pregnancy interceptive agent through restriction of implantation by alteration of gonadal hormone levels and decline in blood-glucose levels that possibly disrupts oxidative energy metabolism in uterus during implantation. High surge in LH and FSH suggests negligible interference in ovulatory mechanism. This preparation also seems to be free of cardiovascular risk factors. HPTLC and HPLC analysis of both EF and AE exhibited marked chemical differences.

• 公益社団法人日本薬学会の論文
• 2006-09-01

著者

• Mukherjee Arup

  Department Of Chemical Technology University Of Calcutta

• Mukherjee Subhendu

  Department Of Chemical Technology University Of Calcutta

• Poddar Kashi

  Clinical Laboratory

• BANERJEE Rita

  Pharmacology Research Unit, Central Research Institute (Ayurveda)

• UPADHYAY Sachchida

  Pharmacology Research Unit, Central Research Institute (Ayurveda)

• HAZRA Jayram

  Pharmacology Research Unit, Central Research Institute (Ayurveda)

• SAHA Achintya

  Department of Chemical Technology, University of Calcutta

• Hazra Jayram

  Pharmacology Research Unit Central Research Institute (ayurveda)

• Saha Achintya

  Department Of Chemical Technology University Of Calcutta

• Banerjee Rita

  Pharmacology Research Unit Central Research Institute (ayurveda)

• Upadhyay Sachchida

  Pharmacology Research Unit Central Research Institute (ayurveda)

• Mukherjee Arup

  Department of Chemical Technology, University of Calcutta

関連論文

• Reproductive Effects of Ethnomedicinal Formulation of Tape-Vine Leaves in Female Rats(Pharmacognosy)
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