Influence of Thermodynamic Parameter in Lanosterol 14α-Demethylase Inhibitory Activity as Antifungal Agents : A QSAR Approach(Medicinal Chemistry)

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概要

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• A quantitative structure activity relationship, Hansch approach was applied on twenty compounds of chromene derivatives as Lanosterol 14α-demethylase inhibitory activity against eight fungal organisms. Various physicochemical descriptors and reported minimum inhibitory concentration values of different fungal organisms were used as independent variables and dependent variable respectively. The best models for eight different fungal organisms were first validated by leave-one-out cross validation procedure. It was revealed that thermodynamic parameters were found to have overall significant correlationship with anti fungal activity and these studies provide an insight to design new molecules.

• 公益社団法人日本薬学会の論文
• 2006-06-01

著者

• Arockia Babu

  Molecular Modeling Laboratory Department Of Pharmacy Shri. G.s. Institute Of Technology And Science

• Lakshmi Manickavasagam

  Faculty Of Pharmacy Babu Banarasi Das National Institute Of Technology And Management

• VASANTHANATHAN Poongavanam

  Faculty of Pharmacy, Babu Banarasi Das National Institute of Technology and Management

• Kaskhedikar Sathish

  Molecular Modeling Laboratory Department Of Pharmacy Shri. G.s. Institute Of Technology And Science

• Vasanthanathan Poongavanam

  Faculty Of Pharmacy Babu Banarasi Das National Institute Of Technology And Management

関連論文

• QSAR Study of 3-Phenyl-5-acyloxymethyl-2H,5H-furan-2-ones as Antifungal Agents : The Dominant Role of Electronic Parameter
• Influence of Thermodynamic Parameter in Lanosterol 14α-Demethylase Inhibitory Activity as Antifungal Agents : A QSAR Approach(Medicinal Chemistry)

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