Pharmacokinetic Study of Ketoprofen Isopropyl Ester-Loaded Lipid Microspheres in Rat Blood Using Microdialysis(Biopharmacy)
スポンサーリンク
概要
- 論文の詳細を見る
A blood microdialysis technique coupled with high-performance liquid chromatography was used to investigate the pharmacokinetics of unbound ketoprofen in rats after intravenous administration of a lipid-soluble ketoprofen derivate, ketoprofen isopropyl ester (KPI), loaded into lipid microspheres (LM) and ketoprofen solution. A microdialysis probe was inserted into the jugular vein of male Wistar rats. KPI-loaded LM or ketoprofen solution (24 mg/kg, i.v.) was then administrated via a femoral vein. Dialysate samples were analyzed using HPLC. The in vitro and in vivo recovery rate of the microdialysis probe was 30.42±0.74% (n=3) and 40.27±2.74% (n=3), respectively. The pharmacokinetic parameters for ketoprofen after intravenous administration of KPI-loaded LM and ketoprofen solution exhibited no statistically significant differences. The results of this pharmacokinetic study indicate that the microdialysis technique can be widely applicable to investigations of in vivo free-drug of microcarrier systems.
- 2006-04-01
著者
-
Cui Fude
Department Of Pharmaceutics Shenyang Pharmaceutical University
-
Tang Xing
Department Of Pharmaceutics Shenyang Pharmaceutical University
-
HE Haibing
Department of Pharmaceutics, Shenyang Pharmaceutical University
-
He Haibing
Department Of Pharmaceutics Shenyang Pharmaceutical University
関連論文
- Preparation of Gel-Core-Solid Lipid Nanoparticle: A Novel Way to Improve the Encapsulation of Protein and Peptide
- Pharmacokinetic Study of Ketoprofen Isopropyl Ester-Loaded Lipid Microspheres in Rat Blood Using Microdialysis(Biopharmacy)
- Formulation, Preparation and Evaluation of an Intravenous Emulsion Containing Brucea Javanica Oil and Coix Seed Oil for Anti-tumor Application(Biopharmacy)
- Errata: Preparation of Gel-Core-Solid Lipid Nanoparticle: A Novel Way to Improve the Encapsulation of Protein and Peptide[Chem. Pharm. Bull. 58(9): 1195-1202 (2010)]
- Pharmacokinetic Interaction between Tanshinones and Polyphenolic Extracts of Salvia miltinorrhiza BUNGE after Intravenous Administration in Rats(Analytical Biochemistry)