Phenolic Constituents of Malus doumeri var. formosana in the Field of Skin Care(Pharmacognosy)

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概要

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• Plant phenolic compounds isolated from a 70% aqueous acetone extract of the leaves of Mains doumeri A. CHEV. var. formosana (KAWAK. & KOIDZ.) S. S. YING, a type of Taiwanese indigenous plant, were evaluated for potential application in the field of skin care. A phytochemical investigation of the active fractions resulted in the isolation of seven compounds of which the structures were identified by spectroscopic characterization. In the present study, the isolated phenolic compounds were evaluated for their free radical-scavenging activities against 1, 1-diphenyl-2-picrylhydrazyl (DPPH) and the superoxide radicals, anti-elastase, and for their anti-matrix metalloproteinase-1 (MMP-1) activity in human skin fibroblast cells. Of these compounds, 3-hydroxyphloridzin (2), 3-hydroxyphloretin (6), and quercetin (7) exhibited the strongest DPPH and superoxide radical-scavenging activities. The IC_<50> values of these compounds were 9.2, 7.7, and 15.4μM, respectively, for the DPPH radical, and 25.0, 19.6, and 42.6μM, respectively, for the superoxide radical. 3-Hydroxyphloridzin (2) and 3-hydroxyphloretin (6) also showed xanthine oxidase inhibitory activity, with IC_<50> values of 52.1 and 22.4μM, respectively. In the test for elastase inhibitory activity, phloretin (5) and 3-hydroxyphloretin (6) were the most potent compounds. Phloretin (5), 3-hydroxyphloretin (6), and quercetin (7) showed better inhibition of MMP-1 production in fibroblast cells. To the best of our knowledge, this is the first time that the active phenolic compounds from M. doumeri var. formosana have been isolated, reported, and described. The above results suggest that the extract of M. doumeri var. formosana containing phenolic compounds could be suitable naturally occurring active constituents for use in anti-aging or cosmetic products.

• 社団法人日本薬学会の論文
• 2006-04-01

著者

• Hsu Feng

  Graduate Institute Of Pharmacognosy Taipei Medical University

• Lee Mei

  Graduate Institute Of Pharmacognosy Taipei Medical University

• LEU Sy

  Graduate Institute of Cell and Molecular Biology, Taipei Medical University

• LIN Yi

  Graduate Institute of Pharmacognosy, Taipei Medical University

• LIN Rong

  Department of Internal Medicine, Ho-Ping Branch, Taipei City Hospital

• WEN Chi

  Seed Improvement and Propagation Station, Council of Agriculture, ROC, Propagation Technology Sectio

• CHENG Kur

  Department of Biochemistry, Taipei Medical University

• Leu Sy

  Graduate Institute Of Cell And Molecular Biology Taipei Medical University

• Lin Rong

  Department Of Cardiology First Hospital Of Quanzhou Affiliated To Fujian Medical University

• Lin Rong

  Department Of Internal Medicine Ho-ping Branch Taipei City Hospital

• Cheng Kur

  Department Of Biochemistry Taipei Medical University

• Lin Yi

  Graduate Institute Of Pharmacognosy Taipei Medical University

• Wen Chi

  Seed Improvement And Propagation Station Council Of Agriculture Roc Propagation Technology Section

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