Immunomodulatory and Anti-inflammatory Effects of Semecarpus anacardium LINN. Nut Milk Extract in Experimental Inflammatory Conditions(Pharmacology)
スポンサーリンク
概要
- 論文の詳細を見る
Immunomodulatory effects of Semecarpus anacardium LINN, nut milk extract (SA) were investigated in adjuvant induced arthritis by studying the alterations in humoral and cell mediated immune responses and also the anti-inflammatory effects by evaluating the changes in paw edema, tumour necrosis factor (TNF-α), nitric oxide and myeloperoxidase activities. Pharmacological studies were also conducted with SA and indomethacin on experimental animals for evaluating the anti-inflammatory, analgesic, antipyretic and ulcerogenic activities. The alterations in the humoral and cell mediated immunity were significantly reverted back to near normal levels on treatment with SA. The drug significantly reduced the elevation in the paw edema, TNF-α, nitric oxide and myeloperoxidase levels when compared with adjuvant induced arthritic animals, which shows the anti-inflammatory activity of the drug. SA showed strong anti-inflammatory effects in xylene-induced ear edema and formalin-induced inflammation. In analgesic test, the extract elicited a potential activity on both acetic acid-induced writhing response as well as hot plate test showing its central and peripheral mediated action. The drug also elicited antipyretic action in yeast-induced hyperemia in rats. In addition, the extract did not produce any ulceration on gastric mucosa during ulcerogenic test and did not produce any serious adverse effects. All these effects are nearly similar to the activities of indomethacin except the ulceration where indomethacin produced significant ulceration. From this study, the protective immunological and pharmacological role of SA is demonstrated.
- 公益社団法人日本薬学会の論文
- 2006-04-01
著者
-
Ramprasath Vanu
Department Of Medical Biochemistry Dr. Alm Post Graduate Institute Of Basic Medical Sciences Univers
-
Shanthi Palanivelu
Department Of Pathology Dr. Alm Post Graduate Institute Of Basic Medical Sciences University Of Madr
-
Shanthi Palanivelu
Department Of Pathology Dr. A. L. Mudaliar Post-graduate Institute Of Basic Medical Sciences Univers
-
Sachdanandam Panchanatham
Department Of Medical Biochemistry Dr. Alm Post Graduate Institute Of Basic Medical Sciences Univers
-
Sachdanandam Panchanatham
Department Of Medical Biochemistry Dr. A. L. Mudaliar Post-graduate Institute Of Basic Medical Scien
関連論文
- Effect of Coenzyme Q_, Riboflavin and Niacin on Serum CEA and CA 15-3 Levels in Breast Cancer Patients Undergoing Tamoxifen Therapy(Pharmacology)
- Free Radical Quenching and Immunomodulatory Effect of a Modified Siddha Preparation, Kalpaamruthaa
- Anticancer Effect of Kalpaamruthaa on Mammary Carcinoma in Rats with Reference to Glycoprotein Components, Lysosomal and Marker Enzymes(Pharmacology)
- Biochemical Evaluation of Glycoprotein Components, Lysosomal Enzymes and Marker Enzymes upon Kalpaamruthaa Administration in Experimental Mammary Carcinoma Rats
- Therapeutic Efficacy of Kalpaamruthaa on Lipid Peroxidation and Antioxidant Status in Experimental Mammary Carcinoma in Rats
- Immunomodulatory and Anti-inflammatory Effects of Semecarpus anacardium LINN. Nut Milk Extract in Experimental Inflammatory Conditions(Pharmacology)
- Anti-inflammatory Effect of Semecarpus anacardium LINN. Nut Extract in Acute and Chronic Inflammatory Conditions(Pharmacology)
- Oral Acute and Subacute Toxicity Studies with Kalpaamruthaa, a Modified Indigenous Preparation, on Rats