Immunogenicity of mini-cells prepared from Salmonella typhimurium

概要

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Immunogenicity of mini-cells of an avirulent strain λ9 of Salmonella typhimurium was examined by antilethal infection immunity, bactericidal activity of macrophages and by histopathological studies of livers of immunized mice. Similar to mice immunized with live whole cells of λ9 strain, mice immunized with mini-cells acquired anti-infection immunity against intraperitoneal challenge with LT_2 strain of S. typhimurium, while no anti-infection immunity was observed in mice immunized with heat-killed whole cells of S. typhimurium. Macrophages collected from mice which had been immunized with mini-cells exhibited enhancing bactericidal activity against Salmonella cells, while no enhancement of bactericidal activity was observed in macrophoges collected from mice which had been immunized with heat-killed whole cells. Moreover, by histopathological study, granuloma formation was observed in the livers of mice which were immunized with mini-cells or live whole cells, but not in those of mice immunized with heat-killed whole cells. These results strongly suggested that mini-cells have immunogenic properties similar to those of live whole cells of S. typhimurium.
群馬大学の論文
1983-03-30