Macrophage chemotaxis inhibitory factor in tumor-bearing hosts

概要

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Macrophage chemotaxis was inhibited by tumorgenic ascites suggesting the presence of macrophage chemotaxis inhibitory factor (MCIF). MCIF inhibited chemotaxis not only of syngeneic but also of xenogeneic macrophages through the depression of macrophage adherence. MCIF was heat-labile, and its activity was lost within 3 days at 4℃ but was preserved 2 month at -80℃. MCIF which was assayed with xenogeneic mouse macrophages was found from early stage in sera of human patients with mammary carcinoma. Ia-negative macrophages were more sensitive to MCIF than Ia-positive macrophages suggesting that nonspecific macrophage activities such as chemotactic or digestive activities were at first depressed in tumor-bearing hosts and that the depression of such activities might cause relaps of tumor cells or serious infection in tumor-bearing hosts.
群馬大学の論文
1982-03-10