Candida albicansの生物学と病原性

概要

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The imperfect, dimorphic fungus Candida albicans is a widespread commensal of human and other animals recovered from oral cavity, alimentary tracts and vagina, and is clinically isolated as an opportunistic pathogen. The incidence of both superficial and systemic candidiasis has been increased markedly over the last few decades. Some reasons for this are due to iatrogenic factors such as long-term-uses of broad-spectrum antibiotics, immunosuppressive agents and indwelling catheters to compromised hosts. In an attempt to survey some developments and future trends of the basic researches of this medically important fungus, this review endeavors to summarize recent papers dealing with the basic problems and subjects described below. Those are as follows : 1) taxonomy and nomenclature ; 2) dimorphism including environmental factors to promote morphological transition, physiological and biochemical changes during the transition, and a glucose effect of the fungus ; 3) adherence and fungal toxins or toxic metabolites presumably associated with pathogenicity ; 4) host defense mechanisms ; and 5) basic problems of antifungal agents and chemotherapy.
鹿児島大学の論文
1988-03-26