EVS2-4 Reversal of allergen-induced airway remodeling by CysLT_1 receptor blockade

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概要

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• In summary, our studies indicate that CysLT_1 receptor antagonism has a significant anti-airway remodeling effect in an animal model of human asthma. The reversal of established airway structural changes (i.e., increased smooth muscle mass and subepithelial fibrosis) by montelukast, but not dexamethasone, suggests an important role for cysteinyl leukotrienes in the immunopathogenesis of the remodeling process that is not modulated by corticosteroids. Clinical studies in patients with asthma to determine the alterability of established airway structural changes by CysLT_1 receptor blockade will be of great interest.

• 一般社団法人日本アレルギー学会の論文
• 2006-09-30

著者

• Henderson Jr.

  Center For Allergy And Inflammation Department Of Medicine University Of Washington

• William R.

  Center for Allergy and Inflammation, Department of Medicine, University of Washington

関連論文

• EVS2-4 Reversal of allergen-induced airway remodeling by CysLT_1 receptor blockade

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