ラット顎下腺の発育に伴うBMPおよびその受容体の局在
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Bone morphogenetic proteins (BMPs) were originally identified as the active components within osteoinductive extracts derived from bone. The BMPs are known to include a large family of proteins within the TGF-β super family of growth factors. More recent studies have shown BMPs are multifunctional cytokines that regulate the proliferation and differentiation of various cell types, function in organogenesis and apoptosis. In order to clarify the role of BMPs in the process of morphogenesis in salivary gland, the expression of BMPs and BMP receptors (BMPRs) were investigated in submandibular gland of developing rat by immunohistochemistry. At fetal 20 days, immunoreactivity of BMP-2 and BMP-4 were detected on some cells in a part of terminal tubule. BMP-2 and BMP-4 positive cells decreased with the progression of acinar differentiation, they were not observed at postnatal 14 days. However, immunoreactivity of BMP-2 and BMP-7 appeared in the ductal cells in postnatal 14 days. Expression of BMPR-I and BMPR-II were observed on some cells in a part of terminal tubule. At birth, they were also expressed in the ductal cells, and increased with age and growth. BMPR-I and BMPR-II positive cells in acinus were not seen at after postnatal 14 days. These results suggest that BMP-2 and BMP-4 are involved in the differentiation of acini, and BMP-2, BMP-7 in the development of the ductal system. In addition, BMP-2, -4, -7 and BMPR-I,-II may have important roles in the morphogenesis of the rat submandibular gland.
- 2006-03-31
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関連論文
- ラット顎下腺の発育に伴うBMPおよびその受容体の局在
- ラット顎下腺の発育に伴うBMPおよびその受容体の局在(奥羽大学大学院歯学研究科博士論文の内容および審査の要旨)
- 1)ラット顎下腺の発育に伴うBMPおよびその受容体の局在(第39回 奥羽大学歯学会例会講演抄録)