Genotoxic Risks to Nurses from Contamination of the Work Environment with Antineoplastic Drugs in Japan
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概要
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The aims of the present study were to clarify the work environment contamination by antineoplastic drugs in a hospital ward and to assess the genotoxic risks to nurses who routinely handle antineoplastic drugs in Japan. The exposed group consisted of 19 female nurses who routinely handled antineoplastic drugs. The control group consisted of 18 female nurses who did not handle antineoplastic drugs in the same hospital as the exposed group. The genotoxicity of the 19 antineoplastic drugs used in the hospital ward and 8 wipe samples of the workbench after handling of antineoplastic drugs were measured using the umu assay. Lymphocyte DNA damage (tail length) was measured with alkaline methods of the single cell gel electrophoresis assay (comet assay). Of the 19 antineoplastic drugs, dacarbazine, bleomycin, daunorubicin, doxorubicin, pirarubicin, carboplatin, cisplatin and etoposide induced genotoxicity. Of the 8 sampling d, the umu activity of the wipe sample was positive on 3 d. Contamination of the workbench was found when the nurses handled more drugs than on other days. The medians of the tail length in the comet assay were 8.5 and 5.1 μm, respectively, for the exposed and control groups, with a significant difference (p=0.004 by Mann-Whitney's U-test). In the present study, the nurses of the exposed group were considered to have been exposed to antineoplastic drugs and lymphocyte DNA damage of the exposed group was suggested to be induced by antineoplastic drugs.
著者
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Yoshida Jin
Department Of Environmental Health Osaka Prefectural Institute Of Public Health
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KOSAKA Hiroshi
Department of Environmental Health, Osaka Prefectural Institute of Public Health
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TOMIOKA Kimiko
Department of Environmental Health, Osaka Prefectural Institute of Public Health
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KUMAGAI Shinji
Department of Environmental Health, Osaka Prefectural Institute of Public Health
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Tomioka Kimiko
Department Of Environmental Health Osaka Prefectural Institute Of Public Health
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Kosaka Hiroshi
Department Of Environmental Health Osaka Prefectural Institute Of Public Health
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Kosaka Hiroshi
Department Of Applied Chemistry Faculty Of Science And Engineering Saga University
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Tomioka Kimiko
Department Of Community Health And Epidemiology Nara Medical University School Of Medicine
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