Anticancer and Anti-inflammatory Sulfur-Containing Semisynthetic Derivatives of Sarcophine

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概要

• 論文の詳細を見る

• Sarcophine (1), a cembranoid diterpene is known to inhibit the process of tumorigenesis. Sarcophine can be isolated in large amounts from the Red Sea soft coral Sarcophyton glaucum and hence is an ideal target for semisynthetic or biocatalytic modifications. Hydroxylated derivatives of 1 were reported to improve its anticancer activity. Despite the promising results and ready availability, there are limited attempts towards further diversifying the library of sarcophine derivatives. Hence, the current study targets the epoxide ring to generate sulfur-containing derivatives of sarcophine by reacting it with ammonium thiocyanate and Lawesson's reagent. Structure elucidation of the products was based on extensive 1D and 2D NMR and high resolution mass spectrometry, in addition to mechanistic considerations. The effect of these derivatives on highly malignant +SA mammary epithialial cell proliferation is reported. Anti-inflammatory potential of sarcophine and its derivatives is also demonstrated.

• 公益社団法人日本薬学会の論文
• 2006-08-01

著者

• YOUSSEF Diaa

  Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University

• EL SAYED

  Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe

• Sawant Swapnali

  Department Of Basic Pharmaceutical Sciences College Of Pharmacy University Of Louisiana At Monroe

• Youssef Diaa

  Department Of Pharmacognosy Faculty Of Pharmacy Suez Canal University

• MAYER Alejandro

  Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University

• SYLVESTER Paul

  Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe

• WALI Vikram

  Department of Basic Pharmaceutical Sciences, College of Pharmacy, University of Louisiana at Monroe

• ARANT Mark

  Department of Chemistry, University of Louisiana at Monroe

• Arant Mark

  Department Of Chemistry University Of Louisiana At Monroe

• Mayer Alejandro

  Department Of Pharmacology Chicago College Of Osteopathic Medicine Midwestern University

• Sylvester Paul

  Department Of Basic Pharmaceutical Sciences College Of Pharmacy University Of Louisiana At Monroe

• Wali Vikram

  Department Of Basic Pharmaceutical Sciences College Of Pharmacy University Of Louisiana At Monroe

• El Sayed

  Department Of Basic Pharmaceutical Sciences College Of Pharmacy University Of Louisiana At Monroe

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