Evaluation of the Anti-inflammatory, Analgesic and Antipyretic Activities of the Natural Polyphenol Chlorogenic Acid(Pharmacology)

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概要

• 論文の詳細を見る

• Phenolic compounds are numerous and ubiquitous in the plant kingdom, being particularly present in health-promoting foods. Epidemiological evidences suggest that the consumption of polyphenol-rich foods reduces the incidence of cancer, coronary heart disease and inflammation. Chlorogenic acid (CGA) is one of the most abundant polyphenol compounds in human diet. Data obtained from in vivo and in vitro experiments show that CGA mostly presents antioxidant and anti-carcinogenic activities. However, the effects of CGA on the inflammatory reaction and on the related pain and fever processes have been explored less so far. Therefore, this study was designed to evaluate the anti-inflammatory, antinociceptive and antipyretic activities of CGA in rats. In comparison to control, CGA at doses 50 and 100mg/kg inhibited carrageenin-induced paw edema beginning at the 2nd hour of the experimental procedure. Furthermore, at doses 50 and 100mg/kg CGA also inhibited the number of flinches in the late phase of formalin-induced pain test. Such activities may be derived from the inhibitory action of CGA in the peripheral synthesis/release of inflammatory mediators involved in these responses. On the other hand, even at the highest tested dose (200mg/kg), CGA did not inhibit the febrile response induced by lipopolysaccharide (LPS) in rats. Additional experiments are necessary in order to clarify the true target for the anti-inflammatory and analgesic effects of CGA.

• 社団法人日本薬学会の論文
• 2006-11-01

著者

• Lopes Norberto

  Universidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto

• Lopes Norberto

  University Of Sao Paulo Faculty Of Pharmaceutical Sciences Of Ribeirao Preto; Avenida Do Cafe S N° C

• SANTOS Michel

  University of Sao Paulo, Faculty of Pharmaceutical Sciences of Ribeirao Preto; Avenida do Cafe s n°,

• ALMEIDA Maria

  University of Sao Paulo, Medical School of Ribeirao Preto; Avenida dos Bandeirantes 3900, Campus Uni

• SOUZA Gloria

  University of Sao Paulo, Faculty of Pharmaceutical Sciences of Ribeirao Preto; Avenida do Cafe s n°,

• Souza Gloria

  University Of Sao Paulo Faculty Of Pharmaceutical Sciences Of Ribeirao Preto; Avenida Do Cafe S N° C

• Almeida Maria

  University Of Sao Paulo Medical School Of Ribeirao Preto; Avenida Dos Bandeirantes 3900 Campus Unive

• Santos Michel

  University Of Sao Paulo Faculty Of Pharmaceutical Sciences Of Ribeirao Preto; Avenida Do Cafe S N° C

• Dos Santos

  Universidade Federal Fluminense Escola De Engenharia Industrial Metalurgica De Volta Redonda

• Lopes Norberto

  Universidade de São Paulo, Faculdade de Ciências Farmacêuticas de Ribeirão Preto

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• Evaluation of the Anti-inflammatory, Analgesic and Antipyretic Activities of the Natural Polyphenol Chlorogenic Acid(Pharmacology)
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