Rat model of ischemic facial nerve paralysis

概要

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Although basic neuropathy research often uses either axotomy or crush models, cases of clinical neuropathy are overwhelmingly caused by ischemic injuries, such as infections and thrombi. Therefore, the nerve damage observed with the axotomy and crush models will generally be greater than the pathophysiology seen in the majority of clinical cases. In order to create neuroparalysis that more closely resembles clinical pathophysiology, we attempted to create an ischemic facial nerve paralysis model using the selective embolization technique. The paralysis created by this model lasted for approximately three days and disappeared completely in about one week. Edema and degeneration were observed in approximately 7% of the entire nerve fiber, suggesting that neuropathy was very slight. In order to determine whether the neuropathy affected the neurotransmitters in this model, we monitored the expression of calcitonin gene-related peptide (CGRP) mRNA in the facial nuclei. Its expression was up-regulated on the operative side. These findings suggest the possibility that the ischemic neuroparalysis model might be a useful animal model for basic research that creates pathophysiologic conditions much closer to clinical cases.
大阪歯科学会の論文