Inhibitory Effect of Ammonium Tetrathiotungstate on Tyrosinase and Its Kinetic Mechanism
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概要
- 論文の詳細を見る
Tyrosinase requires two copper ions at the active site, in order to oxidize phenols to catechols. In this study, the inhibitory effect of the copper-chelating compound, ammonium tetrathiotungstate (ATTT), on the tyrosinase activity was investigated. ATTT was determined to inactivate the activity of mushroom tyrosinase, in a dose-dependent manner. The kinetic substrate reaction revealed that ATTT functions as a kinetically competitive inhibitor in vitro, and that the enzyme-ATTT complex subsequently undergoes a reversible conformational change, resulting in the inactivation of tyrosinase. In human melanin-producing cells, ATTT evidenced a more profound tyrosinase-inhibitory effect than has been seen in the previously identified tyrosinase inhibitors, including kojic acid and hydroquinone. Our results may provide useful information for the development of whitening agent.
- 社団法人日本薬学会の論文
- 2006-09-01
著者
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Yang Jun-mo
韓国
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PARK Kyung-Hee
Department of Electrical Engineering, Chonnam National University
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Park Kyung-hee
Department Of Electrical Engineering Chonnam National University
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Park Kyung-hee
Department Of Molecular Cell Biology Center For Molecular Medicine Samsung Biomedical Research Insti
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Yang Jun-mo
Department Of Dermatology Samsung Medical Center Sungkyunkwan University School Of Medicine
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LEE Jae-Rin
Department of Molecular Cell Biology, Center for Molecular Medicine, Samsung Biomedical Research Ins
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HAHN Hwa-Sun
Department of Molecular Cell Biology, Center for Molecular Medicine, Samsung Biomedical Research Ins
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KIM Young-Hoon
Department of Molecular Cell Biology, Center for Molecular Medicine, Samsung Biomedical Research Ins
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BAE Chang-Dae
Department of Molecular Cell Biology, Center for Molecular Medicine, Samsung Biomedical Research Ins
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OH Sangtaek
PharmcoGenomics Research Center, Inje University
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BAE Yu-Jin
Department of Biotechnology and Bioengineering, and Department of Biomaterial Control, Dong-Eui Univ
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KIM Dong-Eun
Department of Biotechnology and Bioengineering, and Department of Biomaterial Control, Dong-Eui Univ
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HAHN Myong-Joon
Department of Molecular Cell Biology, Center for Molecular Medicine, Samsung Biomedical Research Ins
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Bae Chang-dae
Department Of Molecular Cell Biology Center For Molecular Medicine Samsung Biomedical Research Insti
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Kim Young-hoon
Department Of Cardiology Cardiovascular Center Korea University Anam Hospital
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Kim Young-hoon
Department Of Molecular Cell Biology Center For Molecular Medicine Samsung Biomedical Research Insti
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Yang Jun-mo
Department Of Dermatology Samsung Medical Center School Of Medicine Sungkyunkwan University
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Bae Yu-jin
Department Of Biotechnology And Bioengineering And Department Of Biomaterial Control Dong-eui Univer
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Lee Jae-rin
Department Of Molecular Cell Biology Center For Molecular Medicine Samsung Biomedical Research Insti
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Oh Sangtaek
Pharmcogenomics Research Center Inje University
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Hahn Hwa-sun
Department Of Molecular Cell Biology Center For Molecular Medicine Samsung Biomedical Research Insti
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Kim Dong-eun
Department Of Biotechnology And Bioengineering And Department Of Biomaterial Control Dong-eui Univer
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Kim Dong-eun
Department Of Bioscience And Biotechnology Konkuk University
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Hahn Myong-joon
Department Of Molecular Cell Biology Center For Molecular Medicine Samsung Biomedical Research Insti
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Oh Sangtaek
Pharmacogenomics Research Center Inje University
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Kim Young-Hoon
Department of Applied Physics, Hanyang University, Ansan, Kyunggi-Do 426-791, Korea
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HAHN Myong-Joon
Department of Microbiology, College of Medicine, Kon-Kuk University
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