Evaluation of Antiproliferative Effect in Vitro of Some 2-Amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole Derivatives

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概要

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• New compounds of N-substituted 2-amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole set were synthesized and tested for their antiproliferative activity as part of our research in the antitumour field. Title compounds were obtained by reaction of sulfinylbis (2,4-dihydroxythiobenzoyl) (STB) with 4-substituted 3-thiosemicarbazides. The structures of compounds were identified from elemental, IR, ^1H-, ^<13>C-NMR and MS spectra analyses. The cytotoxicity in vitro against human bladder cancer HCV29T cells was determined. The most active compounds were also tested against human cancer cell lines: SW707 (rectal), A549 (lung) and T47D (breast). The antiproliferative effect of some compounds was higher than cisplatin studied comparatively.

• 公益社団法人日本薬学会の論文
• 2006-07-01

著者

• Matysiak Joanna

  Department Of Chemistry Agricultural University

関連論文

• N-置換およびN,N-二置換2,4-dihydroxythiobenzamide類の合成, 抗菌活性および構造活性相関
• Evaluation of Antiproliferative Effect in Vitro of Some 2-Amino-5-(2,4-dihydroxyphenyl)-1,3,4-thiadiazole Derivatives

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