Effective Preparation of Cycloheptimidazol-4-one Compounds

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概要

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• Effective preparation of cycloheptimidazol-4-ones was developed. The reactions of 2-tosyloxytropone (5) with amidines (6) carried out under simple conditions such as aq. NaOH in toluene at 35℃ afforded the correspending cycloheptimidazol-4-ones (3) in low yield. However, by adding tetra-n-butylammonium bromide (n-Bu_4NBr) to this reaction system, the yield was improved dramatically. The reaction conditions were screened in detail.

• 公益社団法人日本薬学会の論文
• 2006-05-01

著者

• Tomiyama Hiroshi

  Kotobuki Research Laboratories Kotobuki Seiyaku Company Ltd.

• Sonegawa Motoharu

  Kotobuki Research Laboratories Kotobuki Seiyaku Company Ltd.

• Tomiyama Tsuyoshi

  Kotobuki Research Laboratories Kotobuki Seiyaku Company Ltd.

• IWAI Yoshinori

  Kotobuki Research Laboratories, Kotobuki Seiyaku Company, Ltd.

• Iwai Yoshinori

  Kotobuki Research Laboratories Kotobuki Seiyaku Company Ltd.

• TOMIYAMA Tsuyoshi

  Kotobuki Research Laboratories, Kotobuki Seiyaku Company, Ltd.

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• Synthesis and Pharmacological Activity of the Metabolites of Pratosartan
• Regioselective Alkylation of 2-Alkyl-5,6,7,8-tetrahydro-3H-cycloheptimidazol-4-ones and 2-Alkyl-3H-cycloheptimidazol-4-ones
• Effective Preparation of Cycloheptimidazol-4-one Compounds

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