Synthesis and Evaluation as NOP Ligands of Some Spiro[piperidine-4,2'(1'H)-quinazolin]-4'(3'H)-ones and Spiro[piperidine-4,5'(6'H)-[1,2,4]triazolo[1,5-c]quinazolines]

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Some spiro[piperidine-4,2'(1'H)-quinazolin]-4'(3'H)-ones 3 and spiro[piperidine-4,5'(6'H)-[1,2,4]triazolo-[1,5-c]quinazolines] 4 were synthesized and evaluated as ligands of the nociceptin receptor. The examined compounds showed partial agonistic activity, except compounds 3,4n that proved to be pure antagonists.
公益社団法人日本薬学会の論文
2006-05-01