ANTIOXIDANT SUPPLEMENTATION DECREASES THE AMOUNT OF URINARY 8-OHdG EXCRETION INDUCED BY A SINGLE BOUT OF EXERCISE(Proceedings of The 8^<th> Asian Federation of Sports Medicine Congress 2005 Tokyo)

概要

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The purpose of this study was to investigate the intensity of exercise load which increases urinary 8-hydroxydeoxyguanosine (8-OHdG) excretion and the effect of antioxidant supplementation on urinary 8-OHdG excretion after a single bout of exercise. The subjects included 6 healthy males with the following characteristics: age; 24.0±1.1 years, height; 174.0±8.5cm, weight; 71.5±15.4kg, BMI; 23.2±3.4kg/m^2. The urinary concentration of 8-OHdG was measured by the two-column-switching high-performance liquid chromatography (HPLC) method. After 7 days of supplementation, the time course of the urinary 8-OHdG excretion was observed following treadmill running at 70% VO_2max. Significant increases in the urinary 8-OHdG excretion were detected at 2h (p<0.01) and 4h (p<0.05) after exercise. After 7 days of supplementation, a significant increase in the urinary 8-OHdG excretion was detected 1h after exercise (p<0.05); however, it returned to the initial level 2h after exercise. Therefore, oxidative DNA damage induced by a single bout of exercise was diminished by antioxidant supplementation.
2006-10-01