Effects of Cyclic Tensile Forces on the Strength of Fibrous Tissue Examined in an in Vivo Model(<Special Issue>Bioengineering)

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概要

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• Adaptive remodeling of soft fibrous tissues under cyclic tensile forces was investigated. Patellar tendons of rat's knee were harvested and mounted on apparatuses for mechanical stimuli. They were transplanted into the subcutaneous tissues and experienced mechanical stimuli of cyclic tensile forces (1N, 1Hz). Then the tendons were retrieved and their mechanical properties were evaluated with a tensile tester. Four experimental groups were examined in which loading conditions were (1) three times a day (2700 cycles a day) throughout 4 weeks, (2) twice a week (1800 cycles a week) throughout 4 weeks, (3) load-free throughout 4 weeks, or (4) control. Comparing to control group, the tendons in load-free conditions were very weak and shown statistically significant decrease in maximum load, strength and tangent modulus. Contrarily, the tendons in frequent loadings (three times a day) nearly maintained their mechanical properties. Thus the present study clearly elucidated the fact that cyclic tensile forces have significant effects on the mechanical properties of transplanted fibrous tissues.

• 一般社団法人日本機械学会の論文
• 2004-12-15

著者

• Koyama Yoshihisa

  Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

• TAKAKUDA Kazuo

  Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

• Takakuda K

  Tokyo Medical And Dental Univ. Tokyo Jpn

• Takakuda Kazuo

  Department Of Biomechanical Engineering Institute Of Biomaterials And Bioengineering Tokyo Medical A

• Takakuda Kazuo

  Institute For Medical And Dental Engineering Tokyo Medical And Dental University

• Kanaya Tomohiro

  Department Of Biomechanical Engineering Institute Of Biomaterials And Bioengineering Tokyo Medical A

• Koyama Yoshikazu

  Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University

• Muneta T

  Tokyo Medical And Dental Univ. Tokyo Jpn

• Muneta Takeshi

  Graduate School Of Medicine And Dentistry Tokyo Medical And Dental University

• MATSUMOTO Hiroko

  Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University

• KATAKURA Hiroshi

  School of Bionics, Tokyo University of Technology

• Katakura Hiroshi

  School Of Bionics Tokyo University Of Technology

• Matsumoto Hiroko

  Institute Of Biomaterials And Bioengineering Tokyo Medical And Dental University

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