Four New Isoflavonoids from the Stem Bark of Erythrina variegata

概要

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Bioassay-directed fractionation of the stem bark extract of Erythrina variegata L. has resulted in the isolation of three new isoflavones: 5, 4'-dihydroxy-8-(3, 3-dimethylallyl)-2"-methoxyisopropylfurano [4,5:6,7] isoflavone (1), 5, 7, 4'-trihydroxy-6-(3, 3-dimethylallyloxiranylmethyl) isoflavone (2), 5, 4'-dihydroxy-8-(3, 3-dimethylallyl)-2"-hydroxymethyl-2"-methylpyrano [5,6:6,7] isoflavone (3) and a new isoflavanone, 5, 4'-dihydroxy-2'-methoxy-8-(3, 3-dimethylallyl)-2", 2"-dimethylpyrano [5,6:6,7] isoflavanone (4) together with seven known compounds, euchrenone b_<10> (5), isoerysenegalensein E (6), wighteone (7), laburnetin (8), lupiwighteone (9), erythrodiol (10), and oleanolic acid (11). The structures were determined on the basis of spectroscopic analyses and chemical evidence. The effect of these compounds on the proliferation of rat osteogenic sarcoma (UMR106) is also reported.
社団法人日本薬学会の論文
2006-04-01