Direct Determination of p-Hydroxymethamphetamine Glucuronide in Human Urine by High-Performance Liquid Chromatography

スポンサーリンク

概要

• 論文の詳細を見る

• High-performance liquid chromatography (HPLC) with UV detection for the simultaneous determination of the free form of p-hydroxymethamphetamine (p-OHMA) and its metabolite, glucuronide (p-OHMAG) was accomplished for the first time. We achieved this by employing 1) an ion pair reagent for retention of sample to a solid-phase extraction (SPE) cartridge, Sep-Pak Light C18 and 2) a simple two-step stepwise elution technique for subsequent ion pair RP-HPLC. The proposed method was optimized for resolution of p-OHMAG, p-OHMA and MA. The method was successfully applied to urine samples collected from MA abusers.

• 公益社団法人日本薬学会の論文
• 2006-04-01

著者

• Yajima Takehiko

  Faculty Of Pharmaceutical Sciences Toho University

• Aiso Sadakazu

  School Of Medicine Keio University

• Nakajima Rika

  School Of Medicine Keio Univ.

• Nakajima Rika

  School Of Medicine Keio University

• MORISHITA Muneo

  Faculty of Pharmaceutical Sciences, Toho University

• Morishita Muneo

  Faculty Of Pharmaceutical Sciences Toho University

関連論文

• Geographical Pattern of Influenza Propagation in Tokyo and Its Neighborhood in Three Seasons
• Synthesis of Methyl 1-O-(4-Hydroxymethamphetaminyl)-α-D-glucopyranouronate
• Detection Limit Used for Early Warning in Public Health Surveillance
• Factor Analysis of Drug Supply Time Series at Pharmacies
• Quantitative Epidemiological Understanding of Influenza Propagation Process in Tokyo and Environs
• Smoothing of Correlation Functions in the Estimation of the Order of Influenza Infection between Adults and Children
• Stochastic Study on the Sales Pattern of Influenza Anti-Viral Agents at Pharmacies
• Direct Determination of p-Hydroxymethamphetamine Glucuronide in Human Urine by High-Performance Liquid Chromatography

スポンサーリンク