Chemometric Determination of Naproxen Sodium and Pseudoephedrine Hydrochloride in Tablets by HPLC

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概要

• 論文の詳細を見る

• A new chemometric determination by high-performance liquid chromatography (HPLC) with photodiode array (PDA) detection was implemented for the simultaneous determination of naproxen sodium and pseudoephedrine hydrochloride in tablets. Three chemometric calibration techniques, classical least squares (CLS), principle component regression (PCR) and partial least squares (PLS) were applied to the peak area at multiwavelength PDA detector responses. The combinations of HPLC with chemometric calibration techniques were called HPLC-CLS, HPLC-PCR and HPLC-PLS. For comparison purposes the HPLC method called the classic HPLC method was used to confirm the results obtained from combined HPLC-chemometric calibration techniques. A good chromatographic separation between two drugs with losartan potassium as an internal standard was achieved using a Waters Symmetry C18 Column 5μm 4.6±250mm and a mobile phase containing 0.2M acetate buffer and acetonitrile (v/v, 40:60). The multiwavelength PDA detection was measured at five different wavelengths. The chromatograms were recorded as a training set in the mobile phase. Three HPLC-chemometric calibrations and the classic-HPLC method were used to test the synthetic mixtures of naproxen sodium and pseudoephedrine hydrochloride in the presence of the internal standard. The HPLC-chemometric approaches were applied to real samples containing drugs of interest. The experimental results obtained from HPLC-chemo-metric calibrations were compared with those obtained by a classic HPLC method.

• 公益社団法人日本薬学会の論文
• 2006-04-01

著者

• Dinc Erdal

  Department Of Analytical Chemistry Faculty Of Pharmacy Ankara University

• OZDEMIR Abdil

  Department of Chemistry, Faculty of Arts and Sciences, Sakarya University

• AKSOY Halil

  Department of Biochemistry, Faculty of Pharmacy, Marmara University

• USTUNDAG Ozgur

  Department of Analytical Chemistry, Faculty of Pharmacy, Ankara University

• BALEANU Dumitru

  Department of Mathematics and Computer Sciences, Faculty of Arts and Sciences, Cankaya University

• Aksoy Halil

  Department Of Biochemistry Faculty Of Pharmacy Marmara University

• Ozdemir Abdil

  Department Of Chemistry Faculty Of Arts And Sciences Sakarya University

• Ustundag Ozgur

  Department Of Analytical Chemistry Faculty Of Pharmacy Ankara University

• Baleanu Dumitru

  Department Of Mathematics And Computer Sciences Faculty Of Arts And Sciences Cankaya University:nati

関連論文

• Artificial Neural Network Combined with Principal Component Analysis for Resolution of Complex Pharmaceutical Formulations
• Chemometric Determination of Naproxen Sodium and Pseudoephedrine Hydrochloride in Tablets by HPLC
• Mathematical Algorithms Applied to the Multi-linear Regression Functions for the Multicomponent Determination of Pharmaceutical Dosage Form Containing Three-component Mixtures
• Determination of Thiamine HCl and Pyridoxine HCl in Pharmaceutical Preparations Using UV-Visible Spectrophotometry and Genetic Algorithm Based Multivariate Calibration Methods

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