Optimized and Validated Initial-Rate Method for the Determination of Perindopril Erbumine in Tablets

スポンサーリンク

概要

• 論文の詳細を見る

• A simple and sensitive kinetic spectrophotometric method for the determination of perindopril in pharmaceutical preparations is described. The method is based on the interaction of drug with 1-chloro-2, 4-dinitrobenzene (CDNB) in dimethylsulfoxide (DMSO) at 40±1℃. The reaction is followed spectrophotometrically by measuring the rate of change of the absorbance at 420 nm. Under the optimized experimental conditions, the calibration curve showed a linear relationship over the concentration range of 20-140 μg/ml. The activation parameter such as E_a, ΔH, ΔS and ΔG for this reaction were calculated and found to be 27.31 kJ/mol, 24.69 kJ/mol, -138.84 J/K/mol and 61.50 kJ/mol, respectively. The method has been successfully applied to the determination of perindopril in commercial dosage forms. Statistical comparison of the results with the Abdellatef's spectrophotometric method shows excellent agreement and indicates no significant difference between the methods compared in terms of accuracy and precision.

• 公益社団法人日本薬学会の論文
• 2006-01-01

著者

• Rahman Nafisur

  Analytical Chemistry Division Department Of Chemistry Aligarh Muslim University

• ANWAR Nishat

  Analytical Research Division, Department of Chemistry, Aligarh Muslim University

• KASHIF Mohammad

  Analytical Research Division, Department of Chemistry, Aligarh Muslim University

• Kashif Mohammad

  Analytical Research Division Department Of Chemistry Aligarh Muslim University

• Anwar Nishat

  Analytical Research Division Department Of Chemistry Aligarh Muslim University

関連論文

• Kinetic Method for Quantitative Determination of 2-Methyl-1, 4-naphthoquinone in Pure Form and in Pharmaceutical Preparation
• Spectrophotometric Determination of Amlodipine Besylate by Charge-Transfer Complex Formation with p-Chloranilic Acid
• Use of Cerium(IV) Nitrate in the Spectrophotometric Determination of Levodopa and Methyldopa in the Pure Form and Pharmaceutical Preparations
• Optimized and Validated Initial-Rate Method for the Determination of Perindopril Erbumine in Tablets
• Kinetic Spectrophotometric Determination of Famotidine in Commercial Dosage Forms

スポンサーリンク