Displacement of the Beating Heart Induces an Immediate and Sustained Increase in Myocardial Reactive Oxygen Species

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概要

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• Background Heart manipulation and displacement are common maneuvers during beating heart surgery to expose coronary arteries for revascularization. Effects of heart displacement on free radical generation, reactive oxygen species (ROS) have not been previously described. Methods and Results Seven adult male dogs were anesthetized, a left lateral thoracotomy performed to expose the heart, and the coronary sinus cannulated for ROS sampling during different manipulation protocols: (1) heart in normal position; (2) 90 degree manual heart displacement; (3) Trendelenburg position while the heart displaced 90 degrees and (4) return heart to normal resting anatomical position and plus the operating table returned to horizontal. Heart displacement followed by anatomical re-positioning significantly increased the ROS signal as measured by EPR (50-fold compared with control values; p<0.01). Conclusion Trendelenburg positioning and/or repositioning the heart during cardiac surgery may induce acute reperfusion injury and increase ROS.

• 社団法人日本循環器学会の論文
• 2006-08-20

著者

• Tay Stacey

  Centerfor Molecular Medicine

• Liu Shan-lin

  Department Of Biochemistry Shanghai Medical College Of Fudan University Free Radical Regulation Rese

• Mclachlan Craig

  Department Of Pharmacology Department Of Surgery University Of Sydney

• Almsherqi Zakaria

  Department of Physiology, National University of Singapore

• Kostetski louri

  Biophysics Laboratory, Division of Bioengineering, National University of Singapore

• Lai Chung-Sheng

  Department of Surgery & Cardiovascular Surgery, Kaohsiung Medical University

• Chiu Chaw-Chi

  Department of Surgery & Cardiovascular Surgery, Kaohsiung Medical University

• Deng Yuru

  Department of Physiology, National University of Singapore

• Deng Yuru

  Department Of Physiology National University Of Singapore

• Mclachlan Craig

  Department Of Medical And Molecular Biosciences University Of Technology

• Mclachlan Craig

  Department Of Physiology National University Of Singapore:center For Molecular Medicine

• Chiu Chaw-chi

  Department Of Surgery & Cardiovascular Surgery Kaohsiung Medical University

• Kostetski Louri

  Biophysics Laboratory Division Of Bioengineering National University Of Singapore

• Lai Chung-sheng

  Department Of Surgery & Cardiovascular Surgery Kaohsiung Medical University

• Almsherqi Zakaria

  Department Of Physiology National University Of Singapore

• Mclachlan Craig

  Department Of Cardiology University Of Sydney

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