タンパク質のプロトン磁気緩和シミュレーション・プログラムの作成とその応用

概要

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On the two assumptions that the longitudinal magnetic relaxation of protons in proteins is due to only dipole-dipole interaction between protons in the molecule, and that the only one correlation time for isotropic rotation of the whole molecule exists (i. e., the internal motion was neglected), a computer program to calculate the longitudinal relaxation curves for protons in proteins was developed. This program was applied to SSI (Streptomyces subtilisin inhibitor) and the relaxation curves for non-selective inversion, selective inversion and selective saturation measurements were calculated. The characters of the proton relaxation in proteins and probability of application to conformational or motional analysis of proteins were discussed from these calculated relaxation curves.
近畿大学工業高等専門学校の論文
1994-06-15