熱性痙攣の臨床・病態に関する研究
スポンサーリンク
概要
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The purpose of the present study was to elucidate the pathogenesis of the febrile convulsion, using questionaire of the 640 healthy children (18-month-old) on febrile convulsion, follow-up-study of 424 children with febrile convulsion and experimental study of hyperthermia-induced convulsion in developing rabbit. The criteria of febrile convulsion was based on Fukuyama's. The results were as follows : (1) The prevalence rate of febrile convulsion at 18 month old age was 7.3 percent. The 92 percent of 640 healthy children experienced only one or two times of febrile convulsion until 18 month old age. The family history of children with febrile convulsion was 42.6 percent. (2) The electroencephalographic examination of followed up convulsion revealed that EEG abnormalities were 30.5 percent in Kobe University Hospital and 24.4 percent in Himeji Red Cross HospitaL respectively. About a half of EEG abnormalities were focal spikes. The close relationship between EEG abnormalities and numbers of repetition was obtained. The 60 percent of children with more than 5 times of febrile convultion showed EEG abnormalities. (3) The nine children developed recurrent afebrile seizures. Seven out of nine children showed epileptic discharge on EEG and five out of nine experienced more than five times of febrile convulsion. (4) The experimental study on hyperthermia-induced convulsions revealed that susceptibility to experimental febrile convulsion decreased with age in all developing rabbits, and repetiton of experimental febrile convulsions decreased the threshold of convulsion, namely the threshold of elevation of body temperature and· duration of hyperthermia until appearance of convulsion.