糖尿病性血管障害のリスク・ファクターに関する臨床的研究
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概要
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The purpose of the present investigation was the study of platelet adhesiveness, ADP-induced (2μM) platelet aggregation, lipid peroxides and atherogenic index (total cholesterol/HDL-cholesterol ; AI) changes in patients with diabetes mellitus. The comparison made between 46 normal and 150 diabetic subjects. The increase in platelet aggregation and AI were capable of distinguishing the diabetes from normal. The great increase in platelet aggregation was demonstrated in patients with diabetic retinopathy,nephropathy and ishemic heart disease and diabetes. On the other hand, the increase in platelet adhesiveness was not capable in old ages although was capable in young ages. The levels of serum lipid peroxides increased with age in both normal and diabetic subjects, however, the level of serum peroxide in diabetics was higher than in normal in any ages. These findings suggest that atherogenic risk factors are also high levels in diabetic especially diabetics with diabetic angiopahty, and might be contribute not only to atherosclerosis but also to diabetic angiopahty.
- 神戸大学の論文