(4)児の成長後の生活習慣病特に高血圧発症の予防をめざした妊婦栄養管理の基礎的検討 : 栄養組成の視点から(<特集>第58回シンポジウム1「妊娠と栄養・代謝-妊娠中の適切な栄養管理をめざして-」)

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The epidemiological evidences have revealed the association of undernutrition in utero with risk of cardiovascular diseases in the adulthood. The aim of the present study was to investigate the regulatory mechanism of developmental origins of cardiovascular disorders by using mouse animal model of under-nutrition in utero. Maternal food restriction (70% compared to ad libitum control) by regular chow diet (20% protein) induced blood pressure increase as well as cardiac morphological changes, such as cardiomegaly, myocyte hypertrophy and perivascular fibrosis of coronary artery, in the adult offspring. Interestingly, the identical maternal food restriction by high protein diet (40% protein) significantly improved both blood pressure increase and the cardiac morphological changes. It was suggested that the change of fetal corticosterone levels was associated with the improvement of blood pressure increase in the adult offspring with maternal food restriction by high protein diet. By contrast, the change in ontogeny of cardiac local renin angiotensin system was suggested to be involved in the improvement of cardiac morphological changes in the adult offspring with maternal food restriction by high protein diet. Therefore, these findings in the animal studies lead us to an interesting speculation that modulation of protein content in maternal food might protect, at least partly, the developmental origins of cardiovascular disorders.
社団法人日本産科婦人科学会の論文
2006-09-01

(4)児の成長後の生活習慣病特に高血圧発症の予防をめざした妊婦栄養管理の基礎的検討 : 栄養組成の視点から(<特集>第58回シンポジウム1「妊娠と栄養・代謝-妊娠中の適切な栄養管理をめざして-」)

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