Effects of Conformational Factors on Protein Evolution

概要

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This paper describes a step to estimate the role of molecular stability on the selection of amino acid substitution which would occur during the biological evolution of protein. A category of drastic substitution which may correspond to a drastic change of the value of conformational parameter, is applied to the evaluation of the effect of substitution of amino acid residues on the stability of cytochrome c molecule. The evolutional mechanism may be explained as follows: 1, Most of the single drastic substitutions may be rejected by their drastic effect on the molecular stability. But it may be rarely accepted by the compensative effects of neighboring sequence which may presumably be caused by preexisting nondrastic substitutions. 2, Drastic substitution may arouse partially by limited sorts of succeeding nondrastic substitutions rather than it tends to the backmutation. 3, Partially limited nondrastic substitutions and drastic substitutions occuring for a long period may result in the difference of primary structures of cytochrome c among the species.
大阪府立大学の論文
1987-03-31