Experimental Fascioliasis in Monkeys : II. Studies on Liver Function Tests and Electrophoretic Pattern of Serum Protein in Monkeys Infected with the "Japanese Species" of Fasciola

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The alterations in total and individual serum proteins, total serum bilirubin, and various serum enzyme activities were studied in six Macaca monkeys infected with 20 to 100 metacercariae of the "Japanese species" of the liver flukes, Fasciola sp. Infections with metacercariae showed no effect on the serum protein during the first few weeks. Thereafter, in heavily infected monkeys, globulin concentration showed a significant increase, due primarily to a dramatic increase in the gamma-globulin fraction, as the infection progressed. In lightly infected animals, the blood serum showed relatively low levels of globulin concentration. Hypoalbuminemia developed in all the infected monkeys to various degrees. Increased activities of SGOT, SGPT, SLDH, SLAP and SAP were detected in the blood serum of all the infected monkeys, as the infection progressed. Of these enzymes, each pattern of increase in SGOT, SGPT and SLDH was similar. SLAP and SAP activities reached the maximum levels in accordance with the onset of oviposition in the feces. Bilirubinemia, having developed to a moderate degree at later stages of infection in only heavily infected monkeys, appeared not to be a characteristic feature of fascioliasis in monkeys, because in lightly infected animals the bilirubin concentration fluctuated below 1.0 mg per dl throughout the experiment period.
1977-03-31