上皮性卵巣癌におけるAngiopoietin/Tie2 signaling-Vascular endothelial growth factor systemの役割

概要

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The recent discovery of angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) has provided novel and important insights into the molecular mechanisms of blood vessel formation. Ang-1 helps to maintain and stabilize mature vessels by promoting interaction between endothelial cells and surrounding support cells, e.g., pericytes. Ang-2 is expressed at sites of vascular remodeling and is believed to antagonize the stabilizing action of Ang-1. In the presence of vascular endothelial growth factor (VEGF), vessel destabilization by Ang-2 has been hypothesized to induce an angiogenic response. However, in the absence of VEGF, Ang-2 leads to vessel regression. Although the exact role of the angiopoietin/Tie2 system remains enigmatic, the available evidence indicates that the angiopoietin/Tie2 system in the presence of VEGF is important for the initiation of angiogenesis and for vascular sprouting in tumor. The role of angiopoietin/Tie2 system with VEGF in epithelial ovarian cancer has been revealed by molecular biological analysis. A new insight to understand the biology of epithelial ovarian cancer might lead to development of a new molecular target therapy for epithelial ovarian cancer.
香川県立保健医療大学の論文