網膜神経節細胞群の周期的同期発火による視覚誘発性逃避行動の誘発(第23回大会 優秀発表賞抄録)
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概要
- 論文の詳細を見る
In the retinas of frogs synchronized discharges accompanied by γ-range oscillations (the oscillatory synchronization, OS) are generated among OFF-sustained ganglion cells (dimming detectors) in response to a dimming stimulus. We have already shown that an expanding dark spot generates the retinal OS and elicits escape behavior, which is abolished when the OS is suppressed by a GABA_A receptor antagonist. Recently we observed that a GABA_C receptor antagonist, (1,2,5,6-tetrahydropyridine-4-yl) methylphosphinic acid (TPMPA), enhanced the oscillatory activity of dimming detectors. In the present study, we investigated how OS and escape behavior were modulated when TPMPA was applied to the retina. An intraocular injection of TPMPA potentiated escape behavior. Moreover, multi-electrode recordings from isolated retinas revealed that the OS was significantly enhanced by TPMPA. On the other hand, TPMPA did not affect the response properties of other ganglion cells which were not dimming detectors. Furthermore, modulation of the retinal OS by the GABA receptor antagonists was closely related to the changes in escape behavior. Consequently, we conclude that the OS may encode escape-related information.
- 日本基礎心理学会の論文
- 2005-09-30
著者
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本田 祥子
Department Of Psychology Graduate School Of Humanities And Sociology The University Of Tokyo
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雁木 美衣
Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo
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堀内 靖大
Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo
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石金 浩史
Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo
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TACHIBANA Masao
Department of Psychology, Graduate School of Humanities and Sociology, The University of Tokyo
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Tachibana Masao
Department Of Psychology Faculty Of Letters The University Of Tokyo
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雁木 美衣
Department Of Psychology Graduate School Of Humanities And Sociology The University Of Tokyo
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堀内 靖大
Department Of Psychology Graduate School Of Humanities And Sociology The University Of Tokyo
関連論文
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