A Newly Designed Automatic pH-cycling System to Simulate Daily pH Fluctuations

概要

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The aim of this study was to develop and evaluate an automatic pH-cycling system, which was intended for performing time-lapse analyses of dental caries. Two single-section specimens prepared from each of the five extracted human incisors were studied under a condition of 3- or 9-cycles/day for seven weeks. Increase of mineral loss (ΔΔZ) and increase of Ld (ΔLd) were examined and compared at the end of every week during the study. In the 3-cycles/day condition, ΔΔZ and ΔLd significantly increased only at Week 7. In the 9-cycles/day condition, ΔΔZ increased significantly from Week 5.ΔLd increased from Week 2, and then there were no further increases for the subsequent five weeks. Based on the results of this study, progression pattern was found to be significantly different between the two conditions. We therefore concluded that the automatic pH-cycling system which we have developed qualified as a model system that simulated the human oral cavity. As such, it could be beneficially employed to clarify the roles of many factors that cause or prevent caries development in human teeth.
日本歯科理工学会の論文